• Rev Invest Clin · Oct 2020

    Mantle cell lymphoma may have a different clinical course in Mexican Mestizos: Real-world data from a single center.

    • Alejandra C Córdova-Ramírez, Luisa F Sánchez-Valledor, Gerardo Colón-Otero, Montserrat Rivera-Alvarez, Gilberto D Elías-de-la-Cruz, Iván Murrieta-Alvarez, Yahveth Cantero-Fortiz, Andrés León-Peña, Juan C Olivares-Gazca, Guillermo J Ruiz-Delgado, and Guillermo J Ruiz-Argüelles.
    • Centro de Hematología y Medicina Interna de Puebla, Pue.; Universidad Popular Autónoma del Estado de Puebla, Pue.; Mexico.
    • Rev Invest Clin. 2020 Oct 19; 73 (5).

    BackgroundThe biology of some hematological diseases varies among different populations. No previous studies have evaluated the clinical behavior of mantle cell lymphoma (MCL) in México.Objective And MethodsThis is a retrospective review of MCL cases seen in Mexico from January 2003 to June 2020. A total of 12 cases were identified.ResultsThere were nine males and three females; median age was 56 years. Eight patients had a high MCL international prognostic index score, one was intermediate, and three were low. Five patients had circulating malignant monoclonal cells. Initial treatment included rituximab, cyclophosphamide, daunorubicin, vincristine, and prednisone (R-CHOP) and CHOP. Subsequent treatment included hematopoietic stem cell transplantation in five patients; two were given maintenance therapy. Splenectomy was done in four patients. Median overall survival (OS) for all the patients has not been reached and exceeds 162 mos: OS at 162 mos was 56%. Achieving a complete remission (CR) after the first treatment was a significant prognostic factor, with a median OS exceeding 141 mos in patients achieving CR, and 16 mos among those not achieving CR (p = 0.0006).ConclusionSome of MCL patients in Mexico have an indolent clinical course, particularly patients who achieve a CR to initial treatment and who undergo splenectomy.

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