• Xiaojie Ding, Jia Chen, Le Kuai, Meng Xing, Yi Ru, Ying Luo, Yue Luo, Mi Zhou, Bin Li, and Xin Li.
• Department of Dermatology, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine.
• Medicine (Baltimore). 2020 Oct 16; 99 (42): e22786.

RationaleMycosis fungoides (MF) is the most common cutaneous T-cell lymphoma. It appears as patches, plaques, and tumors depending on the stage of the disease, which presents a chronic progressive course. Compared to CD4/CD8 MF, CD4/CD8 dual-positive MF is an uncommon immune phenotype.Patient ConcernsA 36-year-old male patient presented with dryness and scales on his whole body.DiagnosisThe patient was diagnosed with MF based on results of pathological examination, immunohistochemical staining, and T-cell receptor gene rearrangement test.InterventionsThe patient was advised to take an herbal medicine orally twice daily and apply a topical moisturizer after showering.OutcomesAfter treatment and follow-up, the patient's symptoms of dryness and scales improved and his condition stabilized.ConclusionsWhile reviewing the literature, we found no previous reports on the treatment of dual-positive MF with Chinese medicine. In this report, we presented the first case of dual-positive MF successfully treated with Chinese medicine. The results suggest that oral ingestion of herbal medicine may be a feasible method for alleviating clinical symptoms of early stage MF. Therefore, the therapy should be explored for clinical use in the future.

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