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- Zhiping Xie, Wu Zhou, Dan Liu, and Mei-Hua Li.
- Department of Neurosurgery, The First Affiliated Hospital of Nanchang University, Nanchang, China.
- World Neurosurg. 2021 Jan 1; 145: 244-250.
AbstractSpinal cord injuries (SCIs) are difficult to treat. The first animal SCI model (featuring the dropping of a weight) was established by Allen in 1911, and other animal models have been developed since then. Most animal studies have focused only on the molecular features of SCIs, which remain disputed. Recently, it has become clear that SCI may trigger mental and cognitive disorders, however, and brain changes secondary to SCI are under investigation. No consensus on an optimal animal model for cerebral research has emerged. We discuss the appropriate SCI models for studying secondary brain changes.Copyright © 2020 Elsevier Inc. All rights reserved.
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