• Seminars in ophthalmology · Jan 2006

    Review

    The HMG-CoA reductase pathway, statins and angioprevention.

    • Chong Feng, Anjia Han, Caisheng Ye, Rui Xu, and Mengfeng Li.
    • Sun Yat-sen University School of Medicine, Guangzhou GD, PRC.
    • Semin Ophthalmol. 2006 Jan 1; 21 (1): 29-35.

    AbstractAngiogenesis is one of the earliest and essential phenotypes acquired by tumors during carcinogenesis and thus might be a potential target for chemoprevention. Key to developing antiangiogenic chemoprevention is to identify new molecular targets and effective angiogenesis inhibitors. HMG-CoA reductase inhibitors, or statins, were originally designed to reduce cholesterol biosynthesis and have been extensively used as prevention drugs against hyperlipidemia and cardiovascular conditions. Recent research has found that statins promote endothelial death and inhibit experimental angiogenesis induced by growth factors or tumor, laying a foundation for developing statin-based angiopreventive strategies. This article reviews the biological effects of statins on endothelial cells and angiogenesis, possible underlying mechanisms and perspectives on future application of statins in preventing pathological angiogenesis.

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