• E Stekkinger, Rr Scholten, M J van der Vlugt, A P J van Dijk, M C H Janssen, and M E A Spaanderman.
• Department of Obstetrics and Gynaecology, Deventer Hospital, Deventer, the Netherlands. e.stekkinger@dz.nl
• BJOG. 2013 Jul 1; 120 (8): 979-86.

ObjectiveTo compare the prevalence of recurrent pre-eclampsia between women who have and do not have metabolic syndrome when non-pregnant.DesignRetrospective cohort study.SettingThree tertiary referral hospitals in the Netherlands.PopulationFormerly pre-eclamptic women.MethodsThe presence or absence of metabolic syndrome was assessed in 480 women at least 6 months after their first pre-eclamptic pregnancy using World Health Organization criteria. We compared the prevalence of recurrent pre-eclampsia in the subsequent pregnancy, calculating odds ratios (OR), adjusted for confounders.Main Outcome MeasureRecurrence of pre-eclampsia in the subsequent pregnancy.ResultsSubsequent pregnancy outcome data were available for 197 women. Forty women had metabolic syndrome after previous pregnancy (20%). The prevalence of recurrent pre-eclampsia was 18/40 (45%) in women with metabolic syndrome versus 27/157 (17%) in women without metabolic syndrome; OR 3.94 (95% confidence interval [CI] 1.86-8.33, adjusted OR 3.77 (95% CI 1.61-8.81). The risk of recurrent pre-eclampsia increased with each extra component of the metabolic syndrome from 11.8% for absent components up to 43.9% for three or more (P for trend < 0.001).ConclusionsInterpregnancy metabolic syndrome predisposes to recurrent pre-eclampsia.© 2013 The Authors BJOG An International Journal of Obstetrics and Gynaecology © 2013 RCOG.

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