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Int. Immunopharmacol. · May 2019
ReviewChimeric antigen receptor T cell therapy and other therapeutics for malignancies: Combination and opportunity.
- Luyao Wang, Ruixue Yao, Lifa Zhang, Chuanbo Fan, Leina Ma, and Jia Liu.
- Department of Pharmacology, School of Pharmacy, Qingdao University, Qingdao, Shandong 266000, China.
- Int. Immunopharmacol. 2019 May 1; 70: 498-503.
AbstractChimeric antigen receptor T (CAR-T) cell therapy provides possibility for the treatment of malignancies since clinical trials have shown that CAR-T therapy has a significant anti-tumor effect. Although many efforts have been made to improve the efficacy and reduce the side effects of CAR-T therapy, there are still many problems to solve. With the rapid development of this field, combination immunotherapy has been proved to improve the efficacy of CAR-T therapy. Studies have shown that radiotherapy, chemotherapy, oncolytic virotherapy, BTK inhibitors and immune checkpoint blockade-based therapy may further enhance the efficacy of CAR-T therapy while CRISPR/Cas9 technology and IL-1 blockade may improve the safety. In this review, we summarized the advantages and the mechanisms of the combination immunotherapy based on CAR-T cell therapy.Copyright © 2019. Published by Elsevier B.V.
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