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Randomized Controlled Trial
CYP2R1 polymorphisms are important modulators of circulating 25-hydroxyvitamin D levels in elderly females with vitamin insufficiency, but not of the response to vitamin D supplementation.
- A Arabi, N Khoueiry-Zgheib, Z Awada, R Mahfouz, L Al-Shaar, M Hoteit, M Rahme, R Baddoura, G Halabi, R Singh, and G El Hajj Fuleihan.
- Calcium Metabolism and Osteoporosis Program, WHO Collaborating Center for Metabolic Bone Disorders, Department of Internal Medicine, American University of Beirut-Medical Center, P.O. Box 11-0236, Riad El-Solh, Beirut, 1107 2020, Lebanon. aa22@aub.edu.lb.
- Osteoporos Int. 2017 Jan 1; 28 (1): 279-290.
AbstractWe studied the association between CYP2R1 genetic polymorphisms and circulating 25-hydroxyvitamin D [25(OH)D] before and after supplementation with vitamin D3 in 218 elderly. We found differences between 3 and 8 ng/ml in circulating levels at baseline in women but not in the response after 1 year of supplementation.
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