• Zhengbao Zhu, Jingyuan Yang, Chongke Zhong, Tan Xu, Aili Wang, Xiaoqing Bu, Yanbo Peng, Hao Peng, Tian Xu, Chung-Shiuan Chen, Yingxian Sun, Jing Chen, Yonghong Zhang, Jiang He, and CATIS Investigation Groups.
• Department of Epidemiology, School of Public Health, Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases, Medical College of Soochow University, Suzhou, Jiangsu, China.
• J. Neurol. Sci. 2017 Aug 15; 379: 177-182.

BackgroundTo examine the effect of abnormal glucose regulation on prognosis and whether hypoglycemic treatment during hospitalization improves prognosis in acute ischemic stroke patients.MethodsA total of 3882 acute ischemic stroke patients with an elevated systolic blood pressure between 140mmHg and 220mmHg were included in the China Antihypertensive Trial in Acute Ischemic Stroke (CATIS). The primary outcome was a combination of death and major disability (modified Rankin Scale score≥3) at 3months after stroke. Secondary outcomes included death, major disability, and vascular events.ResultsCompared with normal fasting plasma glucose, odds ratios (95% confidence interval) associated with impaired fasting glucose (IFG) and diabetes mellitus (DM) were 1.25 (0.92-1.68) and 1.38 (1.13-1.67) for composite outcome of death or major disability, respectively, and there was a significant trend for death or major disability (Ptrend=0.001). A linear association between fasting plasma glucose and the risk of combined outcome of death and major disability was observed among the patients without hypoglycemic treatment during hospitalization (P for linearity=0.005). We found protective effect of hypoglycemic treatment for risk of death (odds ratio, 0.47; 95% confidence interval, 0.24-0.92) among ischemic stroke patients with DM.ConclusionsAbnormal glucose regulation, especially DM, increased risks of 3-month poor outcomes after an acute ischemic stroke and hypoglycemic treatment during hospitalization might improve prognosis in ischemic stroke patients with DM.Copyright © 2017. Published by Elsevier B.V.

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