• Pediatr Crit Care Me · Sep 2004

    Case Reports

    Fomepizole alone for severe infant ethylene glycol poisoning.

    • Thierry Detaille, Pierre Wallemacq, Stephan Clément de Cléty, Roger Vanbinst, Guy Dembour, and Philippe Hantson.
    • Pediatric Intensive Care Unit, St-Luc Hospital, Université catholique de Louvain, Brussels, Belgium.
    • Pediatr Crit Care Me. 2004 Sep 1; 5 (5): 490-1.

    ObjectiveTo report a case of a massive ingestion of ethylene glycol in an infant successfully treated by fomepizole without hemodialysis.DesignDescriptive case report.SettingPediatric intensive care unit.PatientA 5-mo-old boy who ingested 200 mL of an antifreeze solution.InterventionsAntidotal therapy with a total of seven doses of fomepizole administered intravenously with an interval of 12 hrs (15 mg/kg as loading dose, then 10 mg/kg). Hemodialysis was not performed.Measurements And Main ResultsIterative determination of ethylene glycol concentration was obtained in blood and urine. Kinetics were calculated for ethylene glycol and fomepizole elimination. The infant made a complete recovery with no change in renal function.ConclusionsAlthough not yet approved for this indication in the child, fomepizole seemed safe and effective in a case of severe ethylene glycol poisoning, without the need for hemodialysis.

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