• Masafumi Nozoe, Hiroki Kubo, Masashi Kanai, Miho Yamamoto, Shinichi Shimada, and Kyoshi Mase.
• Department of Physical Therapy, Faculty of Nursing and Rehabilitation, Konan Women's University, Kobe, Japan. Electronic address: masafumi.nozoe@gmail.com.
• Nutrition. 2021 Apr 1; 84: 111025.

ObjectivesLower extremity (LE) muscle strength is an important factor for functional outcome in patients with stroke. However, to our knowledge, the factors influencing LE muscle strength in older patients with acute stroke have not been studied. The aim of this study was to investigate the relationships between prestroke sarcopenia risk and comorbidities with LE muscle strength in older patients with acute stroke.MethodsIn this cross-sectional study, we assessed LE muscle strength using the Motricity IUndex (MI), and prestroke sarcopenia risk using SARC-F, a questionnaire for sarcopenia. Multivariate regression analysis was used to investigate the relationship of MI with sarcopenia risk, neurologic deficit assessed by the National Institutes of Health Stroke Scale (NIHSS), and comorbidities in these patients.ResultsWe enrolled 223 patients aged 65 and over with acute stroke (127 men and 96 women; mean age 76 y). Multivariate analyses for MI after adjusting for potential confounders, NIHSS score, diabetes mellitus, and the presence of sarcopenia risk were independently and negatively associated with MI in older patients with stroke (β = -0.775, P < 0.001; β = -0109, P = 0.010; β = -0.097, P = 0.030, respectively).ConclusionsPrestroke sarcopenia and diabetes mellitus are associated with LE muscle strength in older patients with acute stroke, and these assessments would be useful for clinicians.Copyright © 2020 Elsevier Inc. All rights reserved.

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