• Semin Pediatr Neurol · Dec 2009

    The discovery of hypothermic neural rescue therapy for perinatal hypoxic-ischemic encephalopathy.

    • A David Edwards.
    • Division of Clinical Sciences, MRC Clinical Sciences Centre, Hammersmith Hospital, Imperial College London, London, UK. david.edwards@imperial.ac.uk
    • Semin Pediatr Neurol. 2009 Dec 1; 16 (4): 200-6.

    AbstractThe development of the concepts of delayed post-ischaemic neuronal death and neural rescue brought about a search for clinical treatments to reduce brain damage after birth asphyxia. Cooling had long been an unproven empyrical therapy, and a 20 year programme of careful laboratory and clinical research has proved that hypothermia reduces neurological damage in infants suffering perinatal asphyxial encephalopathy.

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