Seminars in pediatric neurology
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Semin Pediatr Neurol · Dec 2009
The discovery of hypothermic neural rescue therapy for perinatal hypoxic-ischemic encephalopathy.
The development of the concepts of delayed post-ischaemic neuronal death and neural rescue brought about a search for clinical treatments to reduce brain damage after birth asphyxia. Cooling had long been an unproven empyrical therapy, and a 20 year programme of careful laboratory and clinical research has proved that hypothermia reduces neurological damage in infants suffering perinatal asphyxial encephalopathy.