• Jon Cacicedo, Alfonso Gómez-Iturriaga, Arturo Navarro, Virginia Morillo, Patricia Willisch, Jose Luis Lopez-Guerra, Ana Illescas, Francisco Casquero, Olga Del Hoyo, Raquel Ciervide, Lorea Martinez-Indart, Pedro Bilbao, and Dirk Rades.
• Department of Radiation Oncology, Hospital Universitario Cruces/Biocruces Health Research Institute, Barakaldo, Spain.
• J Med Imaging Radiat Oncol. 2018 May 23.

IntroductionTo evaluate whether age is a predictor of pain response after radiotherapy for painful bone metastasis (BM).MethodsBetween June 2010 and June 2014, 204 patients with BM undergoing palliative radiotherapy participated in a multicentre prospective study. Patients completed the Brief Pain Inventory (BPI) to rate the intensity pain (from 0 to 10) at baseline and 4 weeks after radiotherapy. To determine which variables predicted pain response and particularly whether age is a predictor, logistic regression analysis was used. Baseline variables considered were: age (≤65/66-75/>75 years), sex, Eastern Cooperative Oncology Group performance status (0-1/≥2), pretreatment pain score (≤4/5-7/≥8), radiotherapy (single/multiple fraction), primary tumour location, visceral metastases (yes/no), concomitant systemic chemotherapy and bisphosphonate use (yes/no).ResultsPain response was assessed in the 128 patients who completed BPI pretreatment and at 4 weeks after radiotherapy. According to univariate analysis, pain response was better in over 75-year-olds than younger patients: (OR, 3.2; 95% CI, 1.1-9.1; P = 0.031). Response was better in patients receiving multiple fractions rather than a single fraction of 8 Gy (OR, 2.8; 95% CI, 1.2-6.1; P = 0.01), and in patients with a pretreatment pain score ≥8 vs ≤7 (OR, 2.4; 95% CI, 1.1-5.0; P = 0.017). No other variables were significant. Multivariate analysis showed that treatment schedule (OR, 3.4; 95% CI 1.4-7.9; P = 0.004) and pre-radiotherapy pain score (OR, 2.8; 95% CI 1.3-6.3; P = 0.009) were the only independent predictors of pain response.ConclusionAll patients with painful bone metastasis should be referred for palliative radiotherapy to relieve the pain regardless of age. Therefore, an older age should not be a reason to withhold palliative radiation treatment.© 2018 The Royal Australian and New Zealand College of Radiologists.

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