• Hiroya Utsumi, Hiroo Terashi, Yohei Ishimura, Tomoko Takazawa, Akito Hayashi, Hideki Mochizuki, Yasuyuki Okuma, Satoshi Orimo, Kazushi Takahashi, Mitsuru Yoneyama, and Hiroshi Mitoma.
• Department of Neurology, Tokyo Medical University, Shinjuku-ku, Japan. utsumi-h@tokyo-med.ac.jp
• Acta Med Okayama. 2012 Jan 1; 66 (1): 31-40.

AbstractTo quantify gait bradykinesia during daily activity in patients with Parkinson's disease (PD), we measured movement-induced accelerations over more than 24h in 50 patients with PD and 17 age-matched normal controls, using a new device, the portable gait rhythmogram. Acceleration values induced by various movements, averaged each 10 min, exhibited a gamma distribution. The mean value of the distribution curve was used as an index of the "amount of overall movement per 24h". Characteristic changes were observed in both the gait cycle and gait acceleration. During hypokinesia, the gait cycle became either faster or slower. A number of patients with marked akinesia/bradykinesia showed a reduced and narrow range of gait acceleration, i.e., a range of floor reaction forces. The results suggest that assessment of the combination of changes in gait cycle and gait acceleration can quantitatively define the severity of gait bradykinesia.

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