• Andrea Russo, Enrico Di Stasio, Alessandro Scagliusi, Francesca Bevilacqua, Maria Antonietta Isgrò, Riccardo Marana, and Elisabetta Marana.
• Department of Anaesthesiology and Intensive Care Medicine, Catholic University of the Sacred Heart in Rome, 00168 Rome, Italy.
• J Clin Anesth. 2013 Jun 1;25(4):314-20.

Study ObjectiveTo determine the effect of positive end-expiratory pressure (PEEP) on the respiratory system and on cardiac function.DesignProspective randomized study.SettingOperating room.Patients60 ASA physical status 1 women scheduled for pelvic laparoscopic surgery.InterventionsPatients were ventilated normally during surgery; PEEP was modified depending on patient group allocation. Group A was the control group and did not receive PEEP. Group B received PEEP 5 cmH2O and Group C received PEEP 10 cmH2O.MeasurementsRespiratory parameters measured were partial pressure of arterial oxygen (PaO2), partial pressure of carbon dioxide (PaCO2), and end-tidal carbon dioxide tension (ETCO2). Cardiac parameters measured were left ventricular end-diastolic volume index (LVEDVI), ie, ratio of LVEDV/body surface area (BSA; [LVEDVI = end-diastolic volume [EDV]/BSA); left ventricular (LV) systolic function, tricuspid annular plane systolic excursion (TAPSE), right ventricular (RV) fractional area change (FAC), RV dimensions in the apical 4-chamber view, tracing basal and mid-cavity minor dimensions and longitudinal dimension, cardiac index, systolic pulmonary artery pressure (PASP), and systolic RV pressure (RVSP). Respiratory and cardiac measurements were recorded at T0 (baseline); T1 (after anesthesia induction, before pneumoperitoneum induction); at 10 (T2), 20 (T3), and 30 (T4) minutes after CO2 insufflation; and at the end of surgery (T5).Main ResultsVentilation with PEEP at 10 cm H2O led to significant improvement in both respiratory and cardiac parameters. A reduction in pulmonary vascular resistance and enhanced washout of expiratory CO2 occurred. Ten and, to a lesser extent, 5 cm H2O of PEEP decreased LV stroke work.ConclusionsVentilation with PEEP (up to 10 cm H2O) recruits the hypoventilated areas of the lungs and reduces cardiac afterload.Copyright © 2013 Elsevier Inc. All rights reserved.

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