• Siyuan Zhu, Jun Xiong, Jun Chen, Genhua Tang, Zhiying Zhong, LunBin Lu, Xingchen Zhou, Han Guo, and Hao Fan.
• Jiangxi University of Traditional Chinese Medicine.
• Medicine (Baltimore). 2020 Oct 23; 99 (43): e22522e22522.

BackgroundLow back pain is a common clinical chronic disease with symptoms of back soreness, numbness, and pain. The incidence of low back pain is high, and gradually increases with age. It is mainly middle-aged and has a high recurrence rate. It is considered to be one of the common diseases with the highest disability rate. The aim of this systematic review is to assess the effectiveness and safety of moxibustion therapy for low back pain.MethodsTwo reviewers will electronically search the following databases: the Cochrane Central Register of Controlled Trials (CENTRAL);PubMed; EMBASE; China National Knowledge Infrastructure (CNKI); Chinese Biomedical Literature Database (CBM); Chinese Scientific Journal Database (VIP database); and Wan-Fang Database from the inception, without restriction of publication status and languages. Additional searching including researches in progress, the reference lists and the citation lists of identified publications. Study selection, data extraction, and assessment of study quality will be performed independently by 2 reviewers. If it is appropriate for a meta-analysis, RevMan 5.4 statistical software will be used; otherwise, a descriptive analysis will be conducted. Data will be synthesized by either the fixed-effects or random-effects model according to a heterogeneity test. The results will be presented as risk ratio (RR) with 95% confidence intervals (CIs) for dichotomous data and weight mean difference (WMD) or standard mean difference (SMD) 95% CIs for continuous data.ResultsThis study will provide a comprehensive review of the available evidence for the treatment of moxibustion with low back pain.ConclusionsThe conclusions of our study will provide an evidence to judge whether moxibustion is an effective and safe intervention for patients with low back pain.Trial Registration NumberINPLASY202080027.

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