• Jae Joon Hwang, Yeon Mok Oh, Chin Kook Rhee, Kwang Ha Yoo, Yong Bum Park, Ho Il Yoon, Seong Yong Lim, Ji Hyun Lee, Eun Kyung Kim, Tae Hyung Kim, Sei Won Lee, Sang Do Lee, Jae Seung Lee, and KOLD Group.
• Department of Pulmonary and Critical Care Medicine, Kyung Hee University Hospital at Gang-Dong, School of Medicine, Kyung Hee University, Seoul, Korea.
• J. Korean Med. Sci. 2020 Mar 2; 35 (8): e58.

BackgroundAlthough the association of hyperuricemia with an increased risk of mortality has been demonstrated in the context of acute exacerbation of chronic obstructive pulmonary disease (COPD), the long-term outcomes of hyperuricemia have not been studied in the case of stable COPD.MethodsWe retrospectively analyzed baseline data of 240 men with stable COPD enrolled in the Korea Obstructive Lung Disease cohort. We evaluated associations between serum uric acid levels and clinical parameters, risk factors for all-cause mortality, and acute exacerbation of COPD.ResultsThe mean age of subjects was 66.4 ± 7.7 years, and the median follow-up time was 5.9 years. We identified no significant difference in terms of lung function or laboratory findings between patients with hyperuricemia and those without. Serum uric acid level was negatively associated with systemic inflammation indicated by neutrophil-lymphocyte ratio (r = -0.211, P = 0.001). Univariate Cox regression analysis revealed hyperuricemia to not be associated with an increased risk of all-cause mortality in men with stable COPD (hazard ratio [HR], 0.580; 95% confidence interval [CI], 0.250-1.370; P = 0.213). In the multivariate Cox regression model, hyperuricemia was not an independent predictor of acute exacerbation (HR, 1.383; 95% CI, 0.977-1.959; P = 0.068).ConclusionAmong men with stable COPD, hyperuricemia is not an independent predictor of all-cause mortality or future acute exacerbation of COPD. These results differ from those of previous studies on patients with acute exacerbation of COPD.© 2020 The Korean Academy of Medical Sciences.

28 keywords...

hide…