• Filippo Migliorini, Nicola Maffulli, Jörg Eschweiler, Marcel Bestch, Markus Tingart, and Alice Baroncini.
• Department of Orthopaedics, RWTH University Clinic Aachen, Aachen, Germany, Pauwelsstraβe 30, 52074 Aachen.
• Br. Med. Bull. 2020 Dec 15; 136 (1): 88-106.

IntroductionLumbar disc herniation (LDH) is a common cause of low back pain (LBP). Recently, in the setting of LBP caused by LDH, a growing interest in ozone therapies has been observed.Source Of DataRecent published literatures.Areas Of AgreementBeing low back pain more common in the elderlies, exploring conservative alternatives to the surgical intervention is of especial interest.Areas Of ControversyEfficacy and feasibility of ozone injections for LDH is debated. Several clinical studies showed controversial results, and the true benefit has not yet been clarified.Growing PointsSystematically summarize current evidences, analyze the quantitative available data and investigate the role of percutaneous ozone therapy for LDH.Areas Timely For Developing ResearchCurrent evidence encourage the use of ozone therapy for LBP from LDH. These conclusions should be interpret in light of the limitations of the present study.© The Author(s) 2020. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oup.com.

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