• Fadwah M Al-Sharif, Shehab M Abd El-Kader, Ziyad A Neamatallah, and Afnan M AlKhateeb.
• Department of Medical Laboratory Technology, Faculty of Applied Medical Sciences, King Abdulaziz University, Jeddah, Saudi Arabia.
• Afr Health Sci. 2020 Jun 1; 20 (2): 897902897-902.

BackgroundActivation of immunological and systemic inflammation markers are common in obesity and asthma.ObjectiveThe target of this study was to assess impact of weight reduction on immunological and systemic inflammation markers in obese asthma patients.Material And MethodsEighty asthmatic patients of both sex; their age and body mass index (BMI) mean were 38.72 ± 7.14 year and 32.65 ± 3.18 Kg/m2 respectively. Exclusion criteria included smokers, infections, vaccinations, cancer, surgery, immune system disorders and medications that may influence immune system function as anti-inflammatory medications, analgesics and anti-depressant. All subjects were randomly enrolled in weight reduction group (group A) or control group (group B).ResultsThe main findings in the present study indicated that weight reducing program in group (A) was associated with significant reduction in the mean values of IL6, TNF-α, and IL8 in addition to significant increase in the mean values of CD4 and CD8 cell count . However, findings of group (B) showed no significant changes. Moreover, Comparison between both groups at the end of the study revealed significant differences.ConclusionWeight reduction improved immunological and systemic inflammation markers in obese asthma patients.© 2020 Al-Sharif FM et al.

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