• Verônica Batista de Albuquerque, Marcelo Augusto de Araújo, Gabriel Thadeu Nogueira Martins Ferreira, Mariana Werneck Fonseca, André Moreira Martins Arruda, Lu ShiChen, and Valéria Nobre Leal de Souza Oliva.
• Department of Veterinary Medicine, Faculty of Veterinary Medicine and Animal Science, Federal University of Mato Grosso do Sul, Campo Grande, MS, Brazil.
• Acta Cir Bras. 2015 Mar 1; 30 (3): 222-38.

PurposeTo investigate cardiorespiratory effects and serum concentration of ropivacaine combined with morphine at different doses.MethodsSixteen healthy adult female dogs weighting 9.8 ± 4.1 kg were included in the study. Twenty minutes after being premedicated with acepromazine and midazolam, the animals were randomly assigned to receive an epidural injection according to each group: RM0.15 = ropivacaine + morphine (0.15 mg kg(-1)) and RM0.2 = ropivacaine + morphine (0.2 mg kg(-1)). Variables recorded consisted of: heart rate and cardiac rhythm, respiratory rate, oxyhemoglobin saturation, inspired oxygen fraction, end-tidal carbon dioxide tension, systolic, mean and diastolic arterial pressures, serum cortisol, plasma ropivacaine and morphine.ResultsSAP, MAP and DAP were significantly increased at TPR in RM0.15 but returned to normal values at the end of the procedure. Arterial pH was decreased in T30 and TESu in both groups and also returned to acceptable ranges at TR. Both PaO2 and PaCO2 were increased along the duration period of the epidural blockade (T30 and TESu) and returned to acceptable values at TR. Serum cortisol was lower at TB, T30 and TR when compared to TESu.ConclusionThe procedures were performed safely and minimal changes in cardiovascular and respiratory variables.

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