• J Clin Anesth · May 2021

    Observational Study

    Impact of nosocomial infections on patient mortality following cardiac surgery.

    • Olga de la Varga-Martínez, Esther Gómez-Sánchez, María Fe Muñoz, Mario Lorenzo, Estefanía Gómez-Pesquera, Rodrigo Poves-Álvarez, Eduardo Tamayo, and María Heredia-Rodríguez.
    • Department of Anaesthesiology, Hospital Clínico Universitario de Valladolid, Valladolid, Spain.
    • J Clin Anesth. 2021 May 1; 69: 110104.

    Study ObjectiveTo determine the rate of nosocomial infection among patients undergoing cardiac surgery and to identify risk factors and the impact of these infections on patient mortality.DesignProspective observational study.SettingIntensive Care Unit (ICU).Patients1097 adult patients who underwent cardiac surgery at Hospital Clínico Universitario de Valladolid between January 2011 and January 2016.InterventionsNone.MeasurementsPreoperative, intraoperative and postoperative medical, surgical and anaesthetic variables.Main ResultsA total of 111 patients (10.1%) acquired a nosocomial infection in the postoperative period. Pneumonia was the most frequent (4.2%) nosocomial infection. Three independent risk factors for the development of a nosocomial infection were identified: cardiopulmonary bypass time, kidney failure and emergency surgery. The stay in the ICU was significantly higher in patients who developed a nosocomial infection (16.6 ± 38.8 vs. 4.4 ± 17.8, P < 0.001). The mortality rate of patients who acquired a nosocomial infection was significantly greater (18%) than that of patients who did not acquire a nosocomial infection (5%) (P < 0.001). The 90-day survival was greater in the group of patients without nosocomial infection (log rank 27.55, P < 0.001). The dynamic modelling of 90-day mortality revealed that in the first week, cardiopulmonary bypass time (HR = 1.00, 95% CI 1.00-1.02, P < 0.001) and emergency surgery (HR = 0.12, 95% CI 0.04-0.37, P < 0.001) were the most important risk factors for mortality, while after the first week, nosocomial infection (HR = 6.23, 95% CI 2.49-15.63, P < 0.001) was the main risk factor, followed by cardiopulmonary bypass time (HR = 1.01, 95% CI 1.00-1.01, P = 0.001) and EuroSCORE (HR = 1.03, 95% CI 1.00-1.06, P = 0.008).ConclusionsNosocomial infections after cardiac surgery constitute the main independent risk factor for mortality after the first week of surgery. These data suggest that its prevention following cardiac surgery must be prioritised to improve patient outcomes.Copyright © 2020 Elsevier Inc. All rights reserved.

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