• British medical bulletin · Dec 2020

    New horizons for idiopathic intracranial hypertension: advances and challenges.

    • Susan P Mollan, Olivia Grech, Zerin Alimajstorovic, Benjamin R Wakerley, and Alexandra J Sinclair.
    • Birmingham Neuro-Ophthalmology, Queen Elizabeth Hospital, Birmingham, UK.
    • Br. Med. Bull. 2020 Dec 15; 136 (1): 118-126.

    IntroductionIdiopathic intracranial hypertension (IIH) is becoming a recognized condition due to the increasing incidence linked to a global obesity epidemic.Sources Of DataAll English papers on PubMed, Cochrane and Scholar between inception until 1 March 2020 were considered.Areas Of AgreementStudies suggest central adiposity has a pathogenic role. Recent weight gain is a risk factor and weight loss has a key role in management.Areas Of ControversyInterpretation of abnormal lumbar puncture opening pressure is debated. There is an increasing recognition of obesity stigma and how this should be approached.Growing PointsFurther evidence is required for the choice of surgical intervention for fulminant IIH. Education regarding IIH should be evidence based.Areas Timely For Developing ResearchNovel research of the pathology of IIH is influencing development of therapies such as glucagon-like peptide-1 receptor agonists and targeting unique androgen signatures. The newly discovered cardiovascular risk requires further attention.© The Author(s) 2020. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oup.com.

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