• Tatjana Sarenac Vulovic, Sladjana Pavlovic, Mitar Lutovac, Vladimir Zdravkovic, Suncica Sreckovic, and Nemanja Zdravkovic.
• Department of Ophthalmology, Faculty of Medical Sciences, Clinical Center Kragujevac, University of Kragujevac, Serbia.
• J Chin Med Assoc. 2019 Oct 14.

BackgroundThe purpose of this study is to reveal the participation of different regulatory cytokines within the process of pseudoexfoliation (PEX).MethodsOur study included 140 patients referred to cataract surgery with early and late stage of pseudoexfoliation syndrome (XFS) or pseudoexfoliation glaucoma (XFG). Humor and serum levels of cytokines TGF-β, PDGF, EGF, IGF, IL-8 and ITAC were measured in a sample using high sensitivity enzyme-linked immunoabsorbent assay (ELISA) kit.ResultsOur results indicate that profibrotic action induced by increasing TGF-β and PDGF locally activates fibrous tissue production in the early XFS with a prolonged effect of PDGF (late XFS) and finally (XFG stage) it is dominantly controlled by EGF and IGF. ITAC overrides angiogenetic effects of IL-8 in XFG.ConclusionBased on our findings local chronic inflammation in the eye is accompanied by the secretion of different profibrotic cytokines (TGF-β, PDGF, EGF, IGF, IL-8) without angiogenesis due to effects of ITAC.

18 keywords...

hide…