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- O Bertel, B Marx, and B Nägeli.
- Ther Umsch. 1989 Jan 1; 46 (1): 15-21.
AbstractSigns of cardiovascular diseases have been found in more than 50% of elderly people over 65 years in industrialized countries. Congestive heart failure is an especially disabling consequence in up to 49% of the age-class 75 to 80 years. Treatment of these patients follows the same guidelines as in younger patients with congestive heart failure; however, treatment results are poor in many instances, and undesirable side effects are frequent. For an adequate management of congestive heart failure in the elderly, one should consider specific age-related changes of the heart muscle cell, of the myocardial structure, of the vessel wall as well as functional changes of cardiovascular regulation, e.g. blunted reflexes and disturbed feed-back loops of hormonal regulation. Moreover, pharmacokinetic and pharmacodynamic properties of medicaments differ in elderly people, which should be considered for an age-adapted specific management of congestive heart failure in this patient-group.
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