• Wien. Klin. Wochenschr. · Apr 2021

    Review

    Clinical manifestations of COVID-19 in the general population: systematic review.

    • da Rosa MesquitaRodrigoRhttp://orcid.org/0000-0002-8212-4853Department of Medicine, Federal University of Alagoas, Arapiraca, Brazil., Francelino Silva JuniorLuiz CarlosLChttp://orcid.org/0000-0002-9934-4174Department of Medicine, Federal University of Alagoas, Arapiraca, Brazil., Santos SantanaFernanda MayaraFMhttp://orcid.org/0000-0001-6920-937XDepartment of Medicine, Federal University of Alagoas, Arapiraca, Brazil., Farias de OliveiraTatianaThttp://orcid.org/0000-0002-4186-6287Department of Medicine, Federal University of Alagoas, Arapiraca, Brazil., Campos AlcântaraRafaelaRhttp://orcid.org/0000-0002-7956-4233Department of Medicine, Federal University of Alagoas, Arapiraca, Brazil., Monteiro ArnozoGabrielGhttp://orcid.org/0000-0001-8567-7085Department of Medicine, Federal University of Alagoas, Arapiraca, Brazil., Rodrigues da Silva FilhoEtvaldoEhttp://orcid.org/0000-0001-7144-1709Department of Medicine, Federal University of Alagoas, Arapiraca, Brazil., Galdino Dos SantosAisla GracieleAGhttp://orcid.org/0000-0002-2119-3855Department of Medicine, Federal University of Alagoas, Arapiraca, Brazil., Oliveira da CunhaEuclides JoséEJhttp://orcid.org/0000-0002-8467-8657Department of Medicine, Federal University of Alagoas, Arapiraca, Brazil., Salgueiro de AquinoSaulo HenriqueSHhttp://orcid.org/0000-0001-7458-1790Department of Medicine, Federal University of Alagoas, Arapiraca, Brazil., and Freire de SouzaCarlos DornelsCDhttp://orcid.org/0000-0001-7995-1893Department of Medicine, Federal University of Alagoas, Arapiraca, Brazil. carlos.freire@arapiraca.ufal.br.Campus Arapiraca, Rodovia AL-115, Bom Sucesso, Federal University of Alagoas, 5730.
    • Department of Medicine, Federal University of Alagoas, Arapiraca, Brazil.
    • Wien. Klin. Wochenschr. 2021 Apr 1; 133 (7-8): 377-382.

    AbstractClinical manifestations of COVID-19 are varied in the general population. This study aimed to systematize the literature regarding clinical manifestations of patients with confirmed COVID-19. A systematic review of the literature was conducted. A total of 8070 scientific productions were found in the databases. Among the studies, 184 met the initial inclusion criteria, with a total of 114,046 patients. After complete reading, 32 studies that did not report clinical manifestations were excluded. The 152 publications finally included a total of 41,409 individuals from at least 23 countries and 26 different clinical manifestations were reported. In percentage terms, 6 symptoms had a general prevalence greater than or equal to 25%, namely, fever (58.66%), cough (54.52%), dyspnea (30.82%), malaise (29.75%), fatigue (28.16%) and sputum/secretion (25.33%). Neurological symptoms (20.82%), dermatological manifestations (20.45%), anorexia (20.26%), myalgia (16.9%), sneezing (14.71%), sore throat (14.41%), rhinitis (14.29%), goosebumps (13.49%), headache (12.17%), chest pain (11.49%) and diarrhea (9.59%) were other common symptoms. Only one study reported dermatological manifestations. The least frequent sign/symptom was hemoptysis (1.65%). In studies with more than 100 patients, the 3 main symptoms were fever (57.93%), cough (54.21%), and dyspnea (30.64%). Dermatological manifestations do not appear among the main symptoms. The identification of all clinical manifestations of COVID-19 is essential for an early diagnosis and the adoption of preventive measures.

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