• Hematol. Oncol. Clin. North Am. · Oct 2016

    Review

    Reversal Agents for the Direct Oral Anticoagulants.

    • Jack E Ansell.
    • Department of Medicine, Hofstra North Shore-LIJ School of Medicine, 500 Hofstra Blvd, Hempstead, NY 11549, USA. Electronic address: ansellje@gmail.com.
    • Hematol. Oncol. Clin. North Am. 2016 Oct 1; 30 (5): 1085-98.

    AbstractThe vitamin K antagonists (VKAs) are associated with a significant rate of major and fatal bleeding complications. The new direct oral anticoagulants (DOACs), even though having a better bleeding profile than the VKAs, are still associated with serious bleeding. The anticoagulation induced by the VKAs can be reversed with both vitamin K and prothrombin complex concentrates, whereas the DOACs were developed without specific reversal agents. Although there is controversy around the necessity of a reversal agent, most clinicians agree that having a reversal agent for the DOACs would be beneficial. Three reversal agents are currently in development.Copyright © 2016 Elsevier Inc. All rights reserved.

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