• Khaled Shawwa, Panagiotis Kompotiatis, Brandon M Wiley, Jacob C Jentzer, and Kianoush B Kashani.
• Division of Nephrology and Hypertension, Department of Medicine, Mayo Clinic, Rochester, MN, USA.
• J Crit Care. 2021 Apr 1; 62: 82-87.

ObjectiveTo describe the associations between right ventricular (RV) function and outcomes of patients with acute kidney injury (AKI) requiring continuous renal replacement therapy (CRRT).MethodsThis is a retrospective study, conducted 2006-2015 at an academic hospital in USA. We included patients with AKI requiring CRRT who had paired echocardiograms within 2 weeks before and after CRRT initiation. We defined improvement in RV systolic function as 2-point improvement on the semiquantitative scale.ResultsThe cohort included 201 patients. The mean(±SD) age was 59(±16) years with 83(41%) female. The median time of the pre and post echocardiograms relative to CRRT initiation were - 1 day (IQR-3;0) prior to and 3 days (IQR1;7) after CRRT initiation. Thirty-one (15%) patients showed an improvement in their RV function. Using a multivariable logistic regression model, improvement in RV systolic function was associated with lower odds of major adverse kidney events (composite of mortality, need for dialysis or persistently elevated serum creatinine) at 90 days with odds ratio (OR) of 0.37(95%CI:0.17-0.84, p.016). Positive cumulative fluid balance was associated with lower odds of improvement in RV function (OR 0.95 per 1-l increase, p 0.045).ConclusionSerial assessment of RV function among patients with AKI requiring CRRT could provide prognostic value.Copyright © 2020. Published by Elsevier Inc.

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