• Bmc Med · Sep 2009

    Review

    Human cellular restriction factors that target HIV-1 replication.

    • Klaus Strebel, Jeremy Luban, and Kuan-Teh Jeang.
    • Laboratory of Molecular Microbiology, NIAID, the National Institutes of Health, Bethesda, Maryland, USA.
    • Bmc Med. 2009 Sep 16; 7: 48.

    AbstractRecent findings have highlighted roles played by innate cellular factors in restricting intracellular viral replication. In this review, we discuss in brief the activities of apolipoprotein B mRNA-editing enzyme 3G (APOBEC3G), bone marrow stromal cell antigen 2 (BST-2), cyclophilin A, tripartite motif protein 5 alpha (Trim5alpha), and cellular microRNAs as examples of host restriction factors that target HIV-1. We point to countermeasures encoded by HIV-1 for moderating the potency of these cellular restriction functions.

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