• Postgrad Med J · Aug 2018

    Review

    Heparin-induced thrombocytopaenia.

    • Mark Prince and Tim Wenham.
    • ST4 in Anaesthesia and Intensive Care, Barnsley Hospital NHS Foundation Trust, Barnsley, UK markprince571@gmail.com.
    • Postgrad Med J. 2018 Aug 1; 94 (1114): 453-457.

    AbstractHeparin-induced thrombocytopaenia (HIT) is a severe and potentially life-threatening adverse drug reaction. Patients become extremely hypercoagulable, and this can lead to life-threatening and limb-threatening thrombosis with a mortality of 5%-10%. HIT is an antibody-mediated process in which platelet activation occurs. Diagnosis requires a high index of suspicion along with a scoring system and laboratory testing. Patients suspected of having HIT must not receive any further heparin or low-molecular weight heparin and must be started on an alternative anticoagulant such as argatroban or danaparoid. Fondaparinux may also be considered but is not licenced for this indication.© Author(s) (or their employer(s)) 2018. No commercial re-use. See rights and permissions. Published by BMJ.

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