• Neuroendocrinol Lett · Mar 2009

    Case Reports

    Repeated occurrence of clozapine-induced myocarditis in a patient with schizoaffective disorder and comorbid Parkinson's disease.

    • Jiri Masopust, Ales Urban, Martin Valis, Radovan Malý, Ivan Tůma, and Ladislav Hosák.
    • Department of Psychiatry, Charles University in Prague, Faculty of Medicine in Hradec Králové, and University Hospital Hradec Králové, Hradec Králové, Czech Republic.
    • Neuroendocrinol Lett. 2009 Mar 1; 30 (1): 19-21.

    AbstractMyocarditis is a rare but life threatening adverse effect of clozapine. Some symptoms of myocarditis--elevated temperature, tachycardia and fatigue--appear commonly during the onset of treatment with clozapine and during the dose titration. We present a case of a patient with concurrent schizoaffective disorder and Parkinson's disease, who twice developed clozapine-induced myocarditis. All symptoms disappeared after the discontinuation of the drug. Early diagnosis, discontinuation of clozapine and supportive therapy of myocarditis lower the risk of a fatal outcome.

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