• Cleve Clin J Med · Mar 2020

    Review Case Reports

    Severe megaloblastic anemia: Vitamin deficiency and other causes.

    • Daniel S Socha, Sherwin I DeSouza, Aron Flagg, Mikkael Sekeres, and Heesun J Rogers.
    • Department of Laboratory Medicine, Robert J. Tomsich Pathology and Laboratory Medicine Institute, Cleveland Clinic.
    • Cleve Clin J Med. 2020 Mar 1; 87 (3): 153-164.

    AbstractMegaloblastic anemia causes macrocytic anemia from ineffective red blood cell production and intramedullary hemolysis. The most common causes are folate (vitamin B9) deficiency and cobalamin (vitamin B12) deficiency. Megaloblastic anemia can be diagnosed based on characteristic morphologic and laboratory findings. However, other benign and neoplastic diseases need to be considered, particularly in severe cases. Therapy involves treating the underlying cause-eg, with vitamin supplementation in cases of deficiency, or with discontinuation of a suspected medication.Copyright © 2020 The Cleveland Clinic Foundation. All Rights Reserved.

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