• Nutrition · Nov 2004

    Histidine supplementation suppresses food intake and fat accumulation in rats.

    • Seiichi Kasaoka, Nobuyo Tsuboyama-Kasaoka, Yumi Kawahara, Setsuko Inoue, Makiko Tsuji, Osamu Ezaki, Hideo Kato, Takahide Tsuchiya, Hiromichi Okuda, and Shigeru Nakajima.
    • Department of Health and Nutrition, Bunkyo University Women's College, Kanagawa, Japan. kasaoka@shonan.bunkyo.ac.jp
    • Nutrition. 2004 Nov 1; 20 (11-12): 991-6.

    ObjectiveHistamine, a derivative of histidine, decreases food intake and body fat by activation of histamine neurons. Our objective was to clarify the effect of dietary histidine, in particular, on food intake and/or body fat accumulation in rats.MethodsMale Wistar rats were assigned to one of four groups after acclimation and allowed free access to diets containing 20% casein (0% histidine), 20% casein plus 1.0% histidine, 20% casein plus 2.5% histidine, or 20% casein plus 5% histidine for 8 d.ResultsFood intake and body weight were recorded daily and compared between groups. During the experimental period, food intake decreased according to the increases in dietary histidine. There was a negative and significant (P < 0.01) correlation between dietary histidine (grams per 8 d) and retroperitoneal fat pad (grams per 100 g of body weight). Uncoupling protein-1 mRNA in brown adipose tissue increased with increases in dietary histidine.ConclusionOur results indicate that dietary histidine suppresses food intake and fat accumulation in rats.

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