• Comput Methods Programs Biomed · May 2019

    Semiparametric competing risks regression under interval censoring using the R package intccr.

    • Jun Park, Giorgos Bakoyannis, and Constantin T Yiannoutsos.
    • Department of Biostatistics Richard M. Fairbanks School of Public Health Indiana University School of Medicine 410 W. 10th Street Suite 3000 Indianapolis, IN 46202, United States of America. Electronic address: jp84@iu.edu.
    • Comput Methods Programs Biomed. 2019 May 1; 173: 167-176.

    Background And ObjectiveCompeting risk data are frequently interval-censored in real-world applications, that is, the exact event time is not precisely observed but is only known to lie between two time points such as clinic visits. This type of data requires special handling because the actual event times are unknown. To deal with this problem we have developed an easy-to-use open-source statistical software.MethodsAn approach to perform semiparametric regression analysis of the cumulative incidence function with interval-censored competing risks data is the sieve maximum likelihood method based on B-splines. An important feature of this approach is that it does not impose restrictive parametric assumptions. Also, this methodology provides semiparametrically efficient estimates. Implementation of this methodology can be easily performed using our new R package intccr.ResultsThe R package intccr performs semiparametric regression analysis of the cumulative incidence function based on interval-censored competing risks data. It supports a large class of models including the proportional odds and the Fine-Gray proportional subdistribution hazards model as special cases. It also provides the estimated cumulative incidence functions for a particular combination of covariate values. The package also provides some data management functionality to handle data sets which are in a long format involving multiple lines of data per subject.ConclusionsThe R package intccr provides a convenient and flexible software for the analysis of the cumulative incidence function based on interval-censored competing risks data.Copyright © 2019 The Authors. Published by Elsevier B.V. All rights reserved.

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