• Clin Neurol Neurosurg · Dec 2018

    Intracranial clear cell meningioma: Clinical study with long-term follow-up in 24 patients.

    • Jiuhong Li, Xueyun Deng, Si Zhang, Qiguang Wang, Jian Cheng, Xiang Li, Daibo Ke, and Xuhui Hui.
    • Department of Neurosurgery, West China Hospital of Sichuan University, Chengdu, Sichuan, China.
    • Clin Neurol Neurosurg. 2018 Dec 1; 175: 74-83.

    ObjectiveClear cell meningioma (CCM) is a rare disease, and controversy about treatment and prognosis of CCMs still exists. We aimed to clarify the natural history, radiological features, histological characteristics, management and prognosis of intracranial CCMs.Patients And MethodsWe performed a retrospective study of 24 patients with intracranial CCM who were treated at West China Hospital from January 2006 to January 2018. The clinical features, radiologic findings, diagnosis, treatment, and outcome of these patients were analyzed retrospectively. Additionally, a literature review of intracranial CCMs was performed.ResultsAmong 3554 surgeries for intracranial meningiomas, we identified 24 (0.7%) cases of CCMs. The most common localization was the frontal lobe (n = 9, 37.5%). The mean age at diagnosis of CCMs was significantly younger than that of total meningiomas patients (46.7 ± 15.8 versus 55.4 ± 14.8 years). They had a high rate (54.2%) of atypical radiological manifestations, such as cystic component, heterogeneous enhancement, and irregular shape. During the average follow-up of 61.1 months, four patients (19.0%) suffered from tumor recurrence. Kaplan-Meier analysis showed that patients with subtotal resection (STR) or a MIB-1 index ≥3% had significantly shorter progression-free survival (PFS) compared to gross total resection (GTR) and MIB-1 index <3%.ConclusionsCCMs are rare diseases which have a predilection to affect younger patients and a high rate of recurrence and metastasis. Surgery resection is the first treatment choice. For patients underwent STR or with MIB-1 index ≥3%, we hold further radiotherapy is necessary. Close follow-up of the brain and spine for years is crucial to monitor recurrence or metastasis.Copyright © 2018 Elsevier B.V. All rights reserved.

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