• David S Knopman, Rebecca F Gottesman, A Richey Sharrett, Amanda L Tapia, Sonia DavisThomas, B Gwen Windham, Laura Coker, Schneider Andrea L C ALC Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, USA., Alvaro Alonso, Josef Coresh, Marilyn S Albert, and Thomas H Mosley.
• Department of Neurology, Mayo Clinic, Rochester, MN, USA. Electronic address: knopman@mayo.edu.
• Alzheimers Dement. 2018 Nov 1; 14 (11): 1406-1415.

IntroductionThe interplay between midlife vascular risk factors and midlife cognitive function with later life mild cognitive impairment (MCI) and dementia (DEM) is not well understood.MethodsIn the Atherosclerosis Risk in Communities Study, cardiovascular risk factors and cognition were assessed in midlife, ages 45-64 years. In 2011-2013, 20-25 years later, all consenting Atherosclerosis Risk in Communities participants underwent a cognitive and neurological evaluation and were given adjudicated diagnoses of cognitively normal, MCI, or DEM.ResultsIn 5995 participants with complete covariate data, midlife diabetes, hypertension, obesity, and hypercholesterolemia were associated with late-life MCI and DEM. Low midlife cognition function was also associated with greater likelihood of late-life MCI or DEM. Both midlife vascular risk factors and midlife cognitive function remained associated with later life MCI or DEM when both were in the model.DiscussionLater life MCI and DEM were independently associated with midlife vascular risk factors and midlife cognition.Copyright © 2018 the Alzheimer's Association. Published by Elsevier Inc. All rights reserved.

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