Alzheimer's & dementia : the journal of the Alzheimer's Association

The most recent articles from: Alzheimers Dement November 2018

Alzheimers Dement · Nov 2018

Midlife vascular risk factors and midlife cognitive status in relation to prevalence of mild cognitive impairment and dementia in later life: The Atherosclerosis Risk in Communities Study.

The interplay between midlife vascular risk factors and midlife cognitive function with later life mild cognitive impairment (MCI) and dementia (DEM) is not well understood. ⋯ Later life MCI and DEM were independently associated with midlife vascular risk factors and midlife cognition.

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Alzheimers Dement · Nov 2018

CSF biomarkers of Alzheimer's disease concord with amyloid-β PET and predict clinical progression: A study of fully automated immunoassays in BioFINDER and ADNI cohorts.

We studied whether fully automated Elecsys cerebrospinal fluid (CSF) immunoassay results were concordant with positron emission tomography (PET) and predicted clinical progression, even with cutoffs established in an independent cohort. ⋯ Elecsys CSF biomarker assays may provide reliable alternatives to PET in Alzheimer's disease diagnosis.

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