• Francesca Ginatempo, Nicola Loi, John C Rothwell, and Franca Deriu.
• Department of Biomedical Sciences, University of Sassari, Sassari, Italy.
• Neuroscience. 2021 Feb 10; 455: 141-150.

AbstractThe process of learning and playing a musical instrument modulates the structural and functional organization of cortical motor networks. In the present study the excitability and short-term functional plasticity of face and hand areas of primary motor cortex (M1) were compared in woodwind musicians (WM), string musicians (SM) and non-musicians (NM) to test the hypothesis that neurophysiological adaptations to the long-term experience of playing a musical instrument are site-specific and related to the particular physiological properties of the representation area in M1. Twenty-two musicians (11 SM, 11 WM) and 11 NM participated in the study. Transcranial magnetic stimulation (TMS) was used to probe rest and active short-latency intracortical inhibition (SICI), interhemispheric inhibition (IHI) and response to paired associative stimulation (PAS). TMS-induced motor evoked potentials (MEP) were recorded from the depressor anguli oris (DAO) and the first dorsal interosseous (FDI) muscles, respectively. Rest and active SICI were the same in all groups (all p > 0.05). WM exhibited significant IHI in the DAO (p = 0.031), in contrast to its absence in SM and NM. Compared with NM and WM, the PAS-induced increase in MEP amplitude in SM was significantly larger in hand M1 (p = 0.008) but not in face M1. In conclusion, neurophysiological adaptations differ between WM, in whom control of the embouchure is highly important, and SM who perform a large range of sequential finger movements and are site-specific in M1.Copyright © 2020 IBRO. Published by Elsevier Ltd. All rights reserved.

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