• J Clin Pharmacol · Sep 2016

    Race-Specific Pharmacodynamic Model of Propofol-Induced Loss of Consciousness.

    • Samsun Lampotang, David E Lizdas, Hartmut Derendorf, Nikolaus Gravenstein, Benjamin Lok, and John P Quarles.
    • Center for Safety, Simulation, and Advanced Learning Technologies, University of Florida, Gainesville, FL, USA.
    • J Clin Pharmacol. 2016 Sep 1; 56 (9): 1141-50.

    AbstractWe present a race-specific model of propofol-induced loss of consciousness that is based on pharmacodynamic data collected and adapted from the peer-reviewed literature. In the proposed race-specific model that includes EC05 and EC95 concentrations, the median (EC50) (and where available 95%CI) propofol concentrations at the effect site compartment for propofol-induced loss of consciousness for whites, Chinese, blacks, and Indians are 2.8 (2.7-2.9), 2.2 (2.2-2.3), 2.0, and 1.9 μg/mL, respectively.© 2016, The American College of Clinical Pharmacology.

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