• Mustafa Ozan Horsanali, Huseyin Eren, Eyup Dıl, Ilke Onur Kazaz, and Hakki Uzun.
• Urology Department, Cigli Training and Research Hospital, Izmir, Turkey.
• Int. J. Clin. Pract. 2021 May 1; 75 (5): e13978.

BackgroundObesity and metabolic syndrome are growing health problems in western countries. Recently reported triglyseride-glucose (TyG) index is a reliable and accessible indicator of metabolic syndrome. TyG index could be used as a indicator of a prognostic risk factor for metabolic syndrome-related cancers.ObjectivesTo investigate the prognostic role of TyG index on oncological outcomes in patients undergoing radical prostatectomy.Design, Setting And ParticipantsData from 200 men who underwent radical prostatectomy were used.Outcome Measurements And Statsitical AnalyseTyG was calculated based on TyG index = Ln [TG (mg/dL) FPG (mg/dL)/2] formula. Patients were divided into two groups according to the 8.55 level as cut-off value for TyG index. Laboratory results, oncological outcomes and survivals were comparised statistically between groups.ResultsMean ages of patients were 64.32 ± 6.1 years and median follow-up time was 61.6 ± 35 (range 4-140) month. Biochemical recurrens was observed in 42 (21%) patients. Positive correlation between TyG index, body mass index, waist circumference, prostate biopsy gleason score, clinical T stage, positive surgical margin, pathological T stage and biochemical recurrence were observed. There was no statistical significance in terms of survival between groups.ConclusionAssociation between TyG index and prostate cancer may facilitate to predict unfavorable prognostic factors of radical prostatectomy. Increased TyG index may use as a predictive marker of positive surgical margin status before radical prostatectomy, BCR, advanced cT and pT stages after radical prostatectomy or worse biopsy gleason score in clinical practice.© 2021 John Wiley & Sons Ltd.

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