International journal of clinical practice
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Int. J. Clin. Pract. · May 2021
Meta AnalysisActive and passive immunization with myelin basic protein as a window for treatment of spinal cord injury; A systematic review and meta-analysis.
Spinal cord injury (SCI), as a dangerous central nervous system damage, continues to threaten communities by imposing various disabilities and costs. These damages may be prevented by adjusting the immune system response using Myelin Basic Protein (MBP) immunization. As a result, the current study is designed to review and analyze the evidence on this subject. ⋯ The results of the present study demonstrated that immunization with MBP, especially in its active form, could significantly improve motor function following SCI. However, the safety of this method is still in debate. Therefore, it is recommended for future research to focus on the investigation of its safety in animal studies, before conducting human clinical trials.
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Int. J. Clin. Pract. · May 2021
Effect of glucagon-like peptide-1 receptor agonists in subjects with type 2 diabetes mellitus: a meta-Analysis.
s We performed a meta-analysis to evaluate the effects of glucagon-like peptide-1 receptor agonists compared to placebo on mortality, cardiovascular, kidney, eye outcomes in subjects with type 2 diabetes mellitus.
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Int. J. Clin. Pract. · May 2021
The effect of adding a training device and smartphone application to traditional verbal counseling in asthmatic children.
New training devices were introduced to help in the inhaler counseling by addressing the inspiratory flow through the metered-dose inhaler (MDI), which is the most important problem of the MDI inhalation technique. This study aimed to compare the effects of MDI traditional verbal counseling and advanced counseling using training devices with a smartphone application in pediatric asthmatic patients. ⋯ The addition of training devices and smartphone applications to traditional verbal counseling of MDI inhalation technique in asthmatic children resulted in significant improvements in lung functions, and duration of inhalation, and progressive decreases in the average number of MDI inhalation techniques errors compared to the verbal counseling group.
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Int. J. Clin. Pract. · May 2021
A randomized double-blind clinical trial: the effectiveness of daily synbiotic supplementation in management of metabolic and periodontal status and inflammatory markers in type-2 diabetes mellitus patients with periodontal disease under nonsurgical-periodontal-therapy.
The purpose of this study was to determine the effectiveness of daily synbiotic supplement in management of patients with type 2 diabetes mellitus (T2DM) and periodontal disease (PD) under non-surgical periodontal therapy (NSPT). ⋯ Synbiotic supplementation with NSPT may be beneficial in improving patients with T2DM and periodontal disease.