• Ah Ran Oh, Jungchan Park, Seung-Hwa Lee, Jihoon Kim, Jong Hwan Lee, Jeong Jin Min, Ji-Hye Kwon, Cheol Won Hyeon, Kwangmo Yang, Jin-Ho Choi, Sang-Chol Lee, and Hyeon-Cheol Gwon.
• From the Department of Anesthesiology and Pain Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea (ARO, JP, JHL, JJM, J-hK, J-hC), Division of Cardiology, Department of Medicine, Heart Vascular Stroke Institute, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea (S-HL, JK, CWH, J-hC,S-CL, H-CG), Department of Emergency Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea (J-hC), Centers for Health Promotion, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea (KY).
• Eur J Anaesthesiol. 2021 Mar 1; 38 (Suppl 1): S33-S40.

BackgroundMyocardial injury after noncardiac surgery (MINS) is one of the most common cardiovascular complications associated with mortality and morbidity during the first 2 years after surgery. However, the relevant variables associated with mortality after discharge in patients with MINS have not been fully investigated.ObjectivesThis study aimed to evaluate the association between persistent inflammation detected by high-sensitivity C-reactive protein (hsCRP) at discharge and postdischarge mortality after MINS.DesignRetrospective observational analysis of acquired data from Samsung Medical Center Troponin in Noncardiac Operation (SMC-TINCO) registry.SettingA tertiary hospital from January 2010 to June 2019.PatientsPatients who were discharged alive after a diagnosis of MINS.Main Outcome MeasuresThe primary endpoint was postdischarge 1-year mortality, and 30-day mortality and the mortality from 30 days to 1 year was also compared.ResultsData from a total of 4545 adult patients were divided into two groups according to hsCRP concentration at discharge. There were 757 (16.7%) patients in the normal hsCRP group and 3788 (83.3%) patients in the elevated hsCRP group. After inverse probability weighting, 1-year mortality was significantly higher in the elevated group than the normal group (hazard ratio 1.93, 95% CI 1.45 to 2.57, P  < 0.001). Thirty-day mortality and the mortality from 30 days to 1 year were also increased in the elevated group.ConclusionIn patients with MINS, an elevated hsCRP concentration at discharge appeared to be associated with increased mortality. Further research is needed to determine whether controlling inflammation can be helpful in reducing mortality.Copyright © 2020 European Society of Anaesthesiology and Intensive Care. Unauthorized reproduction of this article is prohibited.

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