• Eleonora F Orena, Francesco Landucci, Roberta Ayadi, Dario Caldiroli, and Costanza Papagno.
• From the Department of Neurosurgery, Fondazione IRCCS Istituto Neurologico Carlo Besta (EFO, RA, DC), Department of Psychology, Università degli Studi di Milano-Bicocca, Milan (EFO, CP), Department of Anaesthesia and Intensive Care, San Giovanni di Dio Hospital, Florence (FL) and CeRiN and CIMeC, University of Trento, Rovereto, Italy (CP).
• Eur J Anaesthesiol. 2021 Mar 1; 38 (Suppl 1): S50S57S50-S57.

BackgroundMemory priming seems possible even during apparently adequate anaesthesia. However, the effects of different anaesthetics and type of stimuli, by virtue of their specific neural underpinnings, have not been considered.ObjectiveTo determine if intra-operative implicit memory is affected by the type of anaesthesia (propofol or sevoflurane) or by the type of stimuli (abstract or concrete words).DesignTwo consecutive, randomised controlled experiments.SettingNeurological institute in Milan, Italy.PatientsForty-three patients undergoing anaesthesia with propofol (experiment 1) and 32 patients undergoing anaesthesia with sevoflurane (experiment 2). Patients were ASA I or II, age 18 to 65 years, native Italian speakers, right-handed and without any condition affecting memory or hearing.InterventionDuring anaesthesia, the patients heard a list of either concrete or abstract words or no words at all (controls). Explicit memory was tested with an explicit recall task and the Brice Interview; implicit memory was assessed through a word stem completion test.Outcome MeasuresThe number of explicitly recalled words, positivity to the Brice Interview, the proportion of target and nontarget hits, and a derived implicit memory score.ResultsWith propofol, the proportion of target hits was significantly greater than the proportion of nontarget hits for the concrete word experimental group (P = 0.018). The implicit memory score of the concrete word experimental group was significantly higher than the score of both the abstract word experimental group (P  = 0.000) and the concrete word control group (P = 0.023). With sevoflurane, the proportion of target hits was significantly higher than the proportion of nontarget hits for the abstract word experimental group only (P = 0.027). No patients had a BIS above 60 and no one could recall intra-operative events or words.ConclusionIntra-operative memory for words can form during apparently adequate BIS-guided anaesthesia but is modified by propofol or sevoflurane acting on different brain targets. Further studies on larger samples and using neuroimaging techniques are needed.Trial RegistrationClinicaltrials.gov identifier: NCT03727464.Copyright © 2020 European Society of Anaesthesiology and Intensive Care. Unauthorized reproduction of this article is prohibited.

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