• Xue Li, Zhen-Zhen Xu, Yu-Ting Li, Zeng-Mao Lin, Zheng-Ye Liu, and Dong-Xin Wang.
• From the Department of Anesthesiology and Critical Care Medicine, Peking University First Hospital, Beijing, China (XL, Z-ZX, Y-TL, Z-ML, Z-YL, D-XW) and Outcomes Research Consortium, Cleveland, Ohio, USA (D-XW).
• Eur J Anaesthesiol. 2021 Mar 1; 38 (3): 265274265-274.

BackgroundModerate-to-severe pain exists in the early postoperative period after laparoscopic renal surgery.ObjectiveWe investigated the analgesic effect of quadratus lumborum block (QLB) via two approaches in patients undergoing laparoscopic renal nephrectomy.DesignA randomised controlled trial.SettingAn academic tertiary care hospital in Beijing, China.ParticipantsNinety-six patients aged 18 to 70 years who were scheduled for elective laparoscopic radical or partial nephrectomy.InterventionsEligible patients were allocated randomly to a control group (no block), lateral QLB group or posterior QLB group. Ultrasound-guided QLB was performed via either the lateral or posterior approach with 30 ml of 0.4% ropivacaine before surgery.Main Outcome MeasuresThe primary outcome was sufentanil equivalent consumption within 24 h. Among secondary outcomes, somatic and visceral pain intensity at rest and on coughing were assessed with a numerical rating scale (where 0 = no pain and 10 = the worst pain) until 24 h postoperatively.ResultsSufentanil equivalent consumption did not differ among the three groups (118 ± 36 μg in the control group, 115 ± 47 μg in the lateral QLB group and 119 ± 40 μg in the posterior QLB group; P = 0.955). However, both somatic (lateral QLB vs. control, median difference -1, P < 0.001 at rest and -2 to -1, P < 0.001 on coughing; posterior QLB vs. control, -1, P < 0.001 at rest and -2 to -1, P < 0.001 on coughing) and visceral pain scores (lateral QLB vs. control, -1 to 0, P < 0.001 at rest and -1, P < 0.001 on coughing; posterior QLB vs. control, -1 to 0, P < 0.001 at rest and -2 to -1, P < 0.001 on coughing) were significantly lower in the two QLB groups than in the control group.ConclusionFor patients undergoing laparoscopic renal surgery, a pre-operative single-shot QLB via the lateral or posterior approach did not decrease opioid consumption, but improved analgesia for up to 24 h after surgery.Trial Registrationwww.chictr.org.cn identifier: ChiCTR1800019883.Copyright © 2021 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of the European Society of Anaesthesiology.

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