• Ayşe Kevser Demir, Şafak Şahin, Süheyla Uzun Kaya, İlknur Bütün, Rıza Çıtıl, Yalçın Önder, Türker Taşlıyurt, Osman Demir, Köksal Deveci, and Faruk Kutlutürk.
• Gaziosmanpaşa University Faculty of Medicine, Department of Internal Medicine.
• Afr Health Sci. 2020 Mar 1; 20 (1): 277-286.

BackgroundInsulin resistance (IR) is one of the most important etiological risk factors in the development of diabetes. However, there is no clear data regarding the prevalence of IR in the country.ObjectiveThis study evaluates the prevalence of IR and identifies the optimal threshold values for the HOMA indexes in Turkey.MethodsThis cross-sectional, population-based survey includes 2013 participants aged 20-84 years. The values of the anthropometric measurements and laboratory analysis were recorded. The 90th percentile in the non-obese and non-diabetic population was accepted as cut-off values for IR.ResultsThe optimal threshold values for IR were 2.46 in HOMA1-IR and 1.40 in HOMA2-IR. Using the HOMA2-IR method, the overall prevalence of IR was 33.2%. The IR prevalence was higher in women (35.6%) compared to men (30.1%) [p=0.008]. There was a higher IR prevalence in men living in urban areas (p=0.001), not in women. The multivariate logistic regression analysis showed that gender, serum glucose level, serum levels of triglycerides and high-density lipoprotein cholesterol, bodymass index and income status were associated with insulin resistance.ConclusionThe cut-off values of HOMA1-IR and HOMA2-IR were determined in this study and we believe that these findings will be helpful to clinicians in the fight against health problems such as diabetes.© 2020 Demir AK et al.

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