• Nazmabadi Roya, Taheri Fatemeh, Mohammad-Alibeigi Faramarz, Sabzevary-Ghahfarokhi Milad, Sanaei Mohammad-Javad, Salehi-Vanani Najmeh, Mirzaei Yousef, and Bagheri Nader.
• Cellular and Molecular Research Center, Basic Health Sciences Institute, Shahrekord University of Medical Sciences, Shahrekord, Iran.
• Afr Health Sci. 2020 Sep 1; 20 (3): 1264-1272.

BackgroundThe function of the immune system in prostate cancer (PC) might promote carcinogenesis. PC is a common cancer in men. Regulatory B cells (Bregs) are a new subtype of B cells that have suppressive roles in the immune system. Interleukin-10 (IL-10) is a dominant mediator of immune suppression released by Bregs.ObjectiveThe purpose of this research was to examine the frequency of CD19+IL10+ B cells and IL-10 mRNA expression in patients with PC compared to patients with benign prostatic hyperplasia (BPH).MethodsForty paraffin tissue samples from patients with PC and 32 paraffin tissue samples from patients with BPH were entered in this study. The immunohistochemistry staining was used to evaluate the pattern expression of CD19 and IL-10 markers. IL-10 mRNA expression in fresh tissue was determined by real time-polymerase chain reaction (RT-PCR).ResultsThe frequency of CD19+IL-10+ B cells and IL-10 mRNA expression in PC patients were significantly higher than patients with BPH. Also, there was no meaningful relationship between the frequency of IL-10+CD19+ B cells and gleason scores in patients with PC.ConclusionsOur findings suggested that frequency of IL-10+CD19+ B cells correlates with progressive stage of PC.© 2020 Roya N et al.

27 keywords...

hide…