• Neda Farokhzad, Sayed Mostafa Hosseini, Houri Edalat, and Morteza Sadeghi.
• Human Genetics Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran.
• Afr Health Sci. 2020 Sep 1; 20 (3): 1299-1303.

IntroductionPolymorphisms within miRNAs binding sites are associated with miRNAs function. The aim of this study was to investigate the relationship between rs61764370 polymorphism within let-7 miRNA binding site in KRAS gene and the risk of lung cancer in Iranian population.MethodsThis case-control study was conducted with 100 lung cancer patients and 100 healthy persons. The rs61764370 polymorphism was analyzed using PCR-RFLP technique and direct sequencing.ResultsWe found a significant relationship between rs61764370 (T / G) polymorphism and lung cancer risk, the GT genotype (OR: 6.25; 95% CI = 2.605-15.00; P= 0.000) and G allele (OR: 5.25; 95% CI = 2.259-12.208; P= 0.000) were significantly associated with an increased risk of lung cancer.ConclusionAccording to our findings, there is a significant relationship between the KRAS rs61764370 polymorphism and lung cancer risk in Iranian population and this polymorphism may be used as a marker in detection of lung cancer in the future.© 2020 Farokhzad N et al.

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