• F Yilmaz and H Sozel.
• Bratisl Med J. 2021 Jan 1; 122 (1): 49-55.

ObjectivesThe aim of this study was to investigate the association of RDW with all-cause mortality and disease progression in patients with CKD in stage 3-4.MethodsThis longitudinal observational cohort study of patients with CKD was conducted at a single center. We categorized baseline RDW into two groups by its median (14.9 %). The associations between baseline RDW values and all-cause mortality over 56 months were examined in unadjusted and adjusted models. The effect of RDW value on renal outcomes and mortality was evaluated by using Cox regression analysis.ResultsA total of 261 patients were enrolled in the study. During an average follow-up of 56 months, 19.8 % of patients died. The area under the ROC curve for RDW for all-cause mortality was 0.746, with sensitivity of 0.74 and specificity of 0.69 for a cut-off point of 14.3 %. The incidence of all-cause mortality in the group with increased RDW was significantly higher than in the normal RDW group (p < 0.001). The Cox proportional hazard model showed that the elevated RDW level was an independent risk factor for all-cause mortality in patients with CKD in stage 3-4.ConclusionRDW is a powerful and independent prognostic marker for predicting all-cause mortality and disease progression in stage 3-4 of CKD (Tab. 4, Fig. 4, Ref. 29).

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