• Melanie Smith Condeni, Alyson T Basting, Patrick G Costello, Ashley DePriest, Evert A Eriksson, Heather Evans, Kristie Hertel, Andre L Holder, Alyssa N Kester, Kinsey R Kowalski, Carolyn Magee Bell, Barbara McLean, Michael Reichert, Melissa Santibañez, Patrick M Wieruszewski, and Andrea Sikora Newsome.
• Medical University of South Carolina, 150 Ashley Avenue, Charleston, SC 29425, USA. Electronic address: smitmela@musc.edu.
• J Crit Care. 2021 Apr 1; 62: 197-205.

PurposeTo summarize selected meta-analyses and trials related to critical care pharmacotherapy published in 2019.Materials And MethodsThe Critical Care Pharmacotherapy Literature Update (CCPLU) Group screened 36 journals monthly for impactful articles and reviewed 113 articles during 2019 according to Grading of Recommendations, Assessment, Development, and Evaluations (GRADE) criteria.ResultsArticles with a 1A grade, including three clinical practice guidelines, six meta-analyses, and five original research trials are reviewed here from those included in the monthly CCPLU. Clinical practice guidelines on the use of polymyxins and antiarrhythmic drugs in cardiac arrest as well as meta-analyses on antipsychotic use in delirium, stress ulcer prophylaxis (SUP), and vasoactive medications in septic shock and cardiac arrest were summarized. Original research trials evaluated delirium, sedation, neuromuscular blockade, SUP, anticoagulation reversal, and hemostasis.ConclusionThis clinical review and expert opinion provides summary and perspectives of clinical practice impact on influential critical care pharmacotherapy publications in 2019.Copyright © 2020 Elsevier Inc. All rights reserved.

10 keywords...

hide…