• Gabriel Wardi, Christopher R Tainter, Venktesh R Ramnath, Jesse J Brennan, Vaishal Tolia, Edward M Castillo, Renee Y Hsia, Atul Malhotra, Ulrich Schmidt, and Angela Meier.
• Department of Medicine, Division of Pulmonary, Critical Care and Sleep Medicine, University of California San Diego, San Diego, United States of America; Department of Emergency Medicine, University of California San Diego, San Diego, United States of America. Electronic address: gwardi@ucsd.edu.
• J Crit Care. 2021 Apr 1; 62: 212-217.

PurposeSepsis remains amongst the most common causes of death worldwide. It has been described as a disease of the elderly, but contemporary data on risk factors and mortality is lacking.Materials And MethodsMulti-center longitudinal cohort study using non-public, state of California data from January 1, 2008 to September 31, 2015. Patients with sepsis, severe sepsis, and septic shock were identified using ICD-9-CM diagnosis and procedure codes with age subgroups of 18-44, 45-64, 65-74, 75-84, and >85 years old. Descriptive statistics and a single direct logistic regression model were used to present data on incidence and mortality and to identify independent factors associated with mortality.ResultsOf 30,282,159 total inpatient encounters, 20,358,569 met inclusion criteria and 1,566,306 met sepsis criteria. Conditions associated with mortality included metastatic cancer, age, liver disease, residing in a care facility, and a gastrointestinal source of infection as well as fungal infection. Mortality in the >85-year-old subgroup with septic shock was 45.7%, lower than previously reported.ConclusionAge remains an important sepsis risk factor, but other conditions correlated more closely with sepsis-associated death. Patients over 85 years of age suffering from septic shock may have a better chance of survival than previously thought.Copyright © 2020 Elsevier Inc. All rights reserved.

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