• Lei Zhao, Allan Lee, Yu-Hua Fan, Mok Vincent C T VCT Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong 999077, China. , and Lin Shi.
• BrainNow Research Institute, Shenzhen, Guangdong 518000, China.
• Chin. Med. J. 2020 Dec 16; 134 (2): 151-160.

AbstractThe common cerebral small vessel disease (CSVD) neuroimaging features visible on conventional structural magnetic resonance imaging include recent small subcortical infarcts, lacunes, white matter hyperintensities, perivascular spaces, microbleeds, and brain atrophy. The CSVD neuroimaging features have shared and distinct clinical consequences, and the automatic quantification methods for these features are increasingly used in research and clinical settings. This review article explores the recent progress in CSVD neuroimaging feature quantification and provides an overview of the clinical consequences of these CSVD features as well as the possibilities of using these features as endpoints in clinical trials. The added value of CSVD neuroimaging quantification is also discussed for researches focused on the mechanism of CSVD and the prognosis in subjects with CSVD.Copyright © 2020 The Chinese Medical Association, produced by Wolters Kluwer, Inc. under the CC-BY-NC-ND license.

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